South Carolina Small Business Grants & Funding Programs
South Carolina supports small businesses through statewide commerce and innovation partners, local development agencies, and entrepreneur programs serving coastal, manufacturing, and service-based businesses.
Statewide Commerce Support
South Carolina businesses can access support aimed at expansion, job creation, and business growth through statewide commerce and development partners.
Innovation and Research Programs
Startup and innovation-led businesses can pursue commercialization support, founder programs, and research-linked initiatives through statewide and regional partners.
Charleston, Columbia, and Regional Support
Charleston, Columbia, Greenville, and other communities offer local business support, corridor programs, and entrepreneur initiatives for eligible firms.
South Carolina Business Grants
106 grants found
Small Business Innovation Research Grant (SBIR) and Small Business Technology Transfer (SBTT) Program
U.S. Small Business Administration (SBA) business grant opportunities.
SBIR/STTR programs
Small Business Innovation Research and Small Business Technology Transfer programs that provide funding for research and development to small businesses.
USDA Business Programs
USDA’s business programs provide financial backing and technical assistance to stimulate rural business creation and growth.
Skills for Small Business
The Skills for Small Business grant supports businesses with fewer than 100 employees and incentivizes training for new, full-time workers.
NYS-Certified Business Incubator and Innovation Hot Spot Program
Support for early-stage companies varying from physical space to access to capital.
Research and Development Grants
Fund a diverse portfolio of startups and small businesses across technology areas and markets to stimulate technological innovation, meet Federal research and development (R&D) needs, and increase commercialization to transition R&D into impact.
Build to Scale Program
The Build to Scale Program provides funding to support entrepreneurship and innovation
Yégo Action Grant
Provides up to $2,500 in quick-response funding for Native artists and culture bearers who need support to sustain their creative endeavors due to emergencies or unanticipated expenses.
Yéego Action Grant
The Yéego Action Grant provides quick-response funding for Native artists and culture bearers who need support to sustain their creative endeavors due to emergencies or unanticipated expenses.
U.S. National Institutes of Health Grants
The NIH is currently funding grant opportunities related to COVID-19 research.
Breva Thrive Grant
The Breva Thrive Grant awards $5,000 each quarter to small business owners who are making a measurable difference in their local communities.
2026 Pride Fund for LGBTQIA+ Business Owners
The 2026 Pride Fund for LGBTQIA+ Business Owners provides $1,000 microgrants to 20 LGBTQIA+-owned small businesses across the U.S.
Frequently Asked Questions
Common questions about business grants in South Carolina